Thionyl Chloride → HCID 15020185, compound

HRID 1090865Notes

Reaction equation

HRID 1090865 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([OH:14])=O)=[CH:7][CH:6]=1)(=[O:4])=[O:3].S(Cl)([Cl:17])=O>>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([Cl:17])=[O:14])=[CH:7][CH:6]=1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 5723454-Mesylphenylacetic acid

Product 1

HCID 15020185HCID 15020185, compoundYield 101.1%

Conditions

Temperature
90 °C

Procedure

First, a mixture of 110 g (0.51 mole) of 4-methylsulfonylphenylacetic acid and 110 ml (1.51 moles) of thionyl chloride was heated at 90° C. for 2 hours. After completion of the reaction, an excess of thionyl chloride was distilled off under reduced pressure, giving about 120 g of 4-methylsulfonylphenylacetyl chloride as a light brown solid. The solid thus obtained was subjected to the subsequent reaction without isolation and purification.

Workup

  1. customAfter completion of the reaction
  2. distillationan excess of thionyl chloride was distilled off under reduced pressure

Sources & evidence

ORD record
ord-0894f83c7b4d4b8899876da4eee66831
Source dataset
uspto-grants-1992_01
Patent number
US05082974

Reaction notes

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