L-Aspartic Acid → HCID 22842245, compound

Participants

Reaction Steps

A mixture of methyl-4-chlorothiobenzoate (2.11 g, 11.3 mmol), aspartic acid (2.7 g, 2.02 mmol), aq NaOH (3N, 8.8 ml), and Et2O (8 ml) were vigourously stirred at room temperature for 3 days. The aq. layer was separated, acidfied (dil.HCl), and extracted with Et2O (2×25 ml). The combined ether extracts were dried (MgSO4), filtered, and concentrated under reduced pressure to yield N-p-chlorothiobenzoylaspartic acid (0.23 g).

Provenance & Evidence