反应详情

温度

0 °C

In a four neck round bottomed flask 32.4 gm (0.11 mole) of 2-azido-N-(β-Oxo-2,5-dimethoxy phenehyl)-acetamide is prepared according to the step (c) and 260 ml methanol is charged and cooled to 0° C. To this 3.24 gm (0.08 mole) sodium boro hydride is added slowly over a period. After completion of the addition, the reaction mass temperature is raised to 10° C. After completion of the reaction, 10 ml of acetic acid is added. Methanol is stripped off under reduced pressure and the residue obtained is extracted with methylene dichloride. Organic layer is washed with water and methylene dichloride is distilled off. The yield was 95%.

1. additionis charged
2. additionAfter completion of the addition
3. temperaturethe reaction mass temperature is raised to 10° C
4. additionis added
5. customthe residue obtained
6. extractionis extracted with methylene dichloride
7. washOrganic layer is washed with water and methylene dichloride
8. distillationis distilled off