反应详情

On a water bath at about 20° C., a solution of 1.44 g of methyl isothiocyanate in 2 ml of dichloromethane was added dropwise to a mixture of 2.81 g of 2-chloro-5-(methylaminomethyl)pyridine and 10 ml of dichloromethane over a period of 10 minutes and the whole mixture was further stirred for 30 minutes. The reaction mixture was then concentrated and the residue was purified by column chromatography (eluent: dichloromethane-methanol (20:1)) to give 3.33 g of 1-(6-chloro-3-pyridylmethyl)-1,3-dimethylthiourea.

1. concentrationThe reaction mixture was then concentrated
2. customthe residue was purified by column chromatography (eluent: dichloromethane-methanol (20:1))