Methylamine → 1-(1,3-Benzoxazol-2-yl)-N-methylmethanamine

Participants

Reaction Steps

2-(Chloromethyl)benzoxazole (3.99 g, 23.8 mmol) was dissolved in aqueous methylamine (40 mL, 40 wt % in H2O) at 10° C. under a nitrogen atmosphere. After 20 minutes, the reaction mixture was warmed to room temperature and stirred for 1 hour. The mixture was diluted with water and extracted with dichloromethane. The organic phase was dried (MgSO4) and concentrated to afford crude product which was purified by flash column chromatography (5% methanol/dichloromethane) to afford 3.18 g (82%) of pure product as a yellow oil.

Provenance & Evidence