Oxirane, ((4-nitrophenoxy)methyl)-, (R)- → HCID 15675897, compound

Participants

Reaction Conditions

Reaction Steps

2-(Methylaminomethyl)quinoline (5.57 g, 32.41 mmol) in acetonitrile (30 mL) was added to a stirring solution of (R)-(-)-2-[(4-nitrophenoxy)methyl]oxirane (6.32 g, 32.41 mmol) in acetonitrile (90 mL) and the mixture was stirred 18 hours at 60° C., then 48 hours at 20° C. The solvent was removed in vacuo, and the residue was partitioned between ethyl acetate/brine. The organic layer was dried, decolorized, and concentrated to afford crude product which was used directly in the next step.

Provenance & Evidence