4-Hydroxybenzoic Acid → HCID 20083614, compound

HRID 1091115Notes

Reaction equation

HRID 1091115 reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][CH:3]=1.ClC(OCC)=O.C(N1CCOCC1)C.[C:25]([C:27]1[CH:35]=[CH:34][C:30]([CH2:31][CH2:32][NH2:33])=[CH:29][CH:28]=1)#[N:26]>>[C:25]([C:27]1[CH:35]=[CH:34][C:30]([CH2:31][CH2:32][NH:33][C:6]([C:5]2[CH:4]=[CH:3][C:2]([OH:1])=[CH:10][CH:9]=2)=[O:8])=[CH:29][CH:28]=1)#[N:26]

Participants

4

Reactant 3

HCID 1354-Hydroxybenzoic AcidHCID 219125254-(2-Aminoethyl)benzonitrileHCID 86745429HCID 86745429, compound

Product 1

HCID 20083614HCID 20083614, compound

Procedure

The starting material was prepared by reaction of 4-hydroxybenzoic acid with ethyl chloroformate/4-ethylmorpholine and subsequent addition of p-cyanophenethylamine to give p-(p-cyanophenethylcarbamoyl)phenol and then etherification with methyl bromoacetate/KOH in acetone.

Sources & evidence

ORD record
ord-0d31302f0ab24b42bf5afc156c8449de
Source dataset
uspto-grants-1992_01
Patent number
US05084466

Reaction notes

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