Maleic Acid → HCID 67900100, compound

HRID 1091160Notes

Reaction equation

HRID 1091160 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12](=[O:21])[CH:13]=[CH:14][C:15]1[N:16]=[CH:17][NH:18][C:19]=1[CH3:20].[C:22]([OH:29])(=[O:28])/[CH:23]=[CH:24]\[C:25]([OH:27])=[O:26]>>[C:22]([OH:29])(=[O:28])/[CH:23]=[CH:24]\[C:25]([OH:27])=[O:26].[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12](=[O:21])[CH2:13][CH2:14][C:15]1[N:16]=[CH:17][NH:18][C:19]=1[CH3:20]

Participants

3

Reactant 2

HCID 444266Maleic AcidHCID 54074507HCID 54074507, compound

Product 1

HCID 67900100HCID 67900100, compoundYield 64.1%

Procedure

The filtrate from the hydrogenation of 1-(5-fluoro-1-naphthalenyl)-3-(5-methyl-1H-imidazol-4-yl)-2-propen-1-one (1.01 g) was treated with maleic acid (418 mg) and the resultant solution was evaporated to dryness to give a solid. This was recrystallised from methanol/ethyl acetate to give the title compound (920 mg), m.p. 138°-140°.

Workup

  1. customthe resultant solution was evaporated to dryness
  2. customto give a solid
  3. customThis was recrystallised from methanol/ethyl acetate

Sources & evidence

ORD record
ord-4603006b301b4d0fba16dacebd0df645
Source dataset
uspto-grants-1992_01
Patent number
US05084474

Reaction notes

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