HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fluticasone Propionate → Fluticasone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fluticasone Propionate | HCID 444036 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Fluticasone | HCID 5311101 | — |
Reaction Steps
Preferably, the intranasal steroid of the present formulations is fluticasone propionate. Fluticasone propionate is a synthetic corticosteroid and has the empirical formula C25H31F3O5S. It has the chemical name S-(fluromethyl)6α,9-difluoro-11β-17-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate, 17-propionate. Fluticasone propionate is a white to off-white powder with a molecular weight of 500.6 and is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08129364B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-73fa05b8d3b248268b81ebe76ad62501 |
| Source note | uspto-grants-2012_03 |