HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate → (R)-2-(4-chlorophenylcarbamoyl)pyrrolidinium chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate | HCID 9138711 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (R)-2-(4-chlorophenylcarbamoyl)pyrrolidinium chloride | HCID 86607080 | — |
Reaction Steps
4.00 g (12.3 mmol) of tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate are dissolved in 20 ml of 4N HCl in dioxane and left at room temperature for 2 hours. The reaction mixture is evaporated and dried, giving (R)-2-(4-chlorophenylcarbamoyl)pyrrolidinium chloride as a slightly brownish solid; ESI 225.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08129373B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-97a63253abbc4eb99036d1868721737c |
| Source note | uspto-grants-2012_03 |