2-Benzothiazolamine, 6-(4-morpholinyl)- → HCID 24889393, compound

HRID 1091281Notes

Reaction equation

HRID 1091281 reaction equation
[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[N:21]=[C:22]4[N:26]([CH:27]=3)[C:25]3[CH:28]=[CH:29][C:30]([N:32]5[CH2:37][CH2:36]N(C)[CH2:34][CH2:33]5)=[CH:31][C:24]=3[S:23]4)=[CH:16][CH:15]=2)=[O:12])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].N1(C2C=CC3N=C(N)SC=3C=2)CC[O:42]CC1.CN1CCN(C2C=CC3N=C(N)SC=3C=2)CC1>>[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]([NH:13][C:14]2[CH:15]=[CH:16][C:17]([C:20]3[N:21]=[C:22]4[N:26]([CH:27]=3)[C:25]3[CH:28]=[CH:29][C:30]([N:32]5[CH2:33][CH2:34][O:42][CH2:36][CH2:37]5)=[CH:31][C:24]=3[S:23]4)=[CH:18][CH:19]=2)=[O:12])[CH:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 3

HCID 9371972-Benzothiazolamine, 6-(4-morpholinyl)-HCID 24889213HCID 24889213, compoundHCID 39104846HCID 39104846, compound

Product 1

HCID 24889393HCID 24889393, compound

Procedure

1-(5-tert-butyl-isoxazol-3-yl)-3-{4-[7-(4-methyl-piperazin-1-yl)-benzo[d]imidazo[2,1-b]thiazol-2-yl]-phenyl}-urea. was prepared in a manner similar to Steps A-D, except that in Step A, 6-morpholin-4-ylbenzothiazol-2-ylamine was substituted with 6-(4-methylpiperazin-1-yl)-1,3-benzothiazol-2-amine. 1H NMR (CDCl3) δ 9.3 (br, 1H), 7.84 (d and s, 3H), 7.59 (br, 1H), 7.56 (d, 2H), 7.49 (d, 1H), 7.20 (d, 1H), 7.05 (dd, 1H), 5.86 (s, 1H), 3.250 (t, 4H), 2.62 (t, 4H), 2.38 (s, 3H), 1.36 (s, 9H). [Compound A7]

Sources & evidence

ORD record
ord-ef2f923f02254c399bdc2b69cf422097
Source dataset
uspto-grants-2012_03
Patent number
US08129374B2

Reaction notes

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