1-Chloroethyl chloroformate → HCID 66594394, compound

Participants

Reaction Steps

To a solution of (2S)-4-benzyl-2-(5-cyano-2-methoxyphenyl)-morpholine (10.8 g, 35.0 mmol) in 1,2-dichloroethane (80 ml) was added 1-chloroethyl chloroformate (5.73 ml, 52.5 mmol) at room temperature. Upon disappearance of the starting material, the reaction mixture was concentrated under reduced pressure. The residue was then dissolved in methanol (100 ml) and refluxed for 30 minutes. The solvents were removed in vacuo and the residue was filtered and washed with ethyl acetate to afford (2S)-2-(5-cyano-2-methoxyphenyl)-morpholine hydrochloride (8.08 g, 91%) as white solids.

Provenance & Evidence