反应详情

A suspension of 5,6-Dichloro-3H-isobenzofuran-1-one (1.45 g), N-bromosuccinamide (1.27 g) and catalytic benzoyl peroxide in chloroform (30 mL) was heated to reflux for 1 hour. After cooling, the reaction mixture was washed with water, brine, dried (magnesium sulfate), filtered and concentrated to give the sub-title compound as a white solid (1.82 g, 91%). 1H NMR (400 MHz, CDCl3) δ 7.36 (1H, s), 7.77 (1H, s), 8.03 (1H, s) ppm.

1. temperaturewas heated
2. temperatureto reflux for 1 hour
3. temperatureAfter cooling
4. washthe reaction mixture was washed with water, brine
5. dry with materialdried (magnesium sulfate)
6. filtrationfiltered
7. concentrationconcentrated