Trifluoroacetic acid → HCID 59231992, compound

Participants

Reaction Steps

To a solution of t-butyl (4-{7-[(4-acetylpiperazin-1-yl)methyl]-4-aminopyrrolo[2,1-f][1,2,4]triazin-5-yl}-2-fluorophenyl)carbamate (320 mg, 0.62 mmol) in CH2Cl2 (8 ml) was added TFA (3 ml) and was stirred at rt for 3 h. The reaction mixture was partially evaporated and was added 10 ml ethyl acetate and washed with saturated aq. NaHCO3. The organic was dried over Na2SO4, concentrated and purified via column chromatography (95:5, v/v, CH2Cl2-CH3OH) to afford 74 mg of the title compound (yield 30%). 1H-NMR (CH3OH-d4) δ 7.85 (s, 1H), 7.10 to 7.00 (m, 3H), 6.66 (s, 1H), 4.00 (s, 2H), 3.60 to 3.50 (m, 4H), 2.63 to 2.55 (m, 4H), 20.6 (s, 3H); MS [M+H]+=383.9; LCMS RT=1.10 min.

Provenance & Evidence