Trifluoroacetic acid → HCID 59231994, compound

Participants

Reaction Steps

To a suspension of butyl 4-amino-5-{4-[(tert-butoxycarbonyl)amino]phenyl}pyrrolo[2,1-f][1,2,4]triazine-7-carboxylate (174.5 mg, 0.41 mmol) in dichloromethane (4 mL) was added TFA (2 mL). The solution was stirred at rt for 6.5 h and then the volatiles were evaporated under reduced pressure. The residue was dissolved in ethyl acetate (150 mL) and then this solution was washed with saturated aqueous sodium bicarbonate solution and water, dried over sodium sulfate, and concentrated to dryness under reduced pressure to afford 132.7 mg (99%) of the title compound. 1H-NMR (DMSO-d6) δ 8.10 (bs, 1H), 8.02 (s, 1H), 7.10 (d, J=8.3 Hz, 2H), 7.08 (s, 1H), 6.64 (d, J=8.4 Hz, 2H), 5.55 (bs, 1H), 5.34 (s, 2H), 4.24 (t, J=6.5 Hz, 2H), 1.70-1.63 (m, 2H), 1.46-1.37 (m, 2H), 0.93 (t, J=7.4, 3H); MS [M+H]+=326.3; LCMS RT=2.07 min.

Provenance & Evidence