Water → HCID 57599729, compound

HRID 1091522Notes

Reaction equation

HRID 1091522 reaction equation
[NH2:1][C:2]1[C:9]([O:10][CH3:11])=[C:8]([O:12][CH2:13][O:14][CH3:15])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=S.O.[CH2:31](N)[CH2:32][NH2:33]>>[NH:5]1[CH2:31][CH2:32][N:33]=[C:4]1[C:3]1[C:2]([NH2:1])=[C:9]([O:10][CH3:11])[C:8]([O:12][CH2:13][O:14][CH3:15])=[CH:7][CH:6]=1

Participants

5

Reactant 4

HCID 962WaterHCID 3301EthylenediamineHCID 14817Phosphorus sulfide (P2S5)HCID 57599653HCID 57599653, compound

Product 1

HCID 57599729HCID 57599729, compoundYield 51.1%

Procedure

A solution of 2-amino-3-methoxy-4-(methoxymethoxy)benzonitrile 475 mg (2.28 mmol) and phosphorus pentasulfide 25.4 mg (0.11 mmol) in ethylenediamine 2.75 g was stirred at 120° C. for overnight. The reaction mixture was cooled to room temperature and poured into water. The precipitate was collected and washed with water to give the title compound 293 mg as white solid. Yield 51.1%.

Workup

  1. customThe precipitate was collected
  2. washwashed with water

Sources & evidence

ORD record
ord-d9e349da703a456b8a0bd0657ab107da
Source dataset
uspto-grants-2012_03
Patent number
US08129386B2

Reaction notes

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