HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1091533Generated: October 25, 2026
Ethylenediamine → [2-(4,5-dihydro-1H-imidazol-2-yl)-5-(morpholin-4-yl)phenyl]amine
https://huagongshe.com/reaction/1091533
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylenediamine | HCID 3301 | — |
| Reactant | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| Reactant | 2-Amino-4-(4-morpholinyl)benzonitrile | HCID 13499283 | — |
| Product | [2-(4,5-dihydro-1H-imidazol-2-yl)-5-(morpholin-4-yl)phenyl]amine | HCID 57599885 | 83.5% |
Reaction Steps
To a solution of 2-amino-4-(morpholin-4-yl)benzonitrile 3.65 g (18.0 mmol) in ethylenediamine 20mL was added phosphorus pentasulfide 4.00 mg (0.018 mmol) and stirred at 140° C. for 16 hours. After cooling to room temperature, the solvent was evaporated. The residue was washed with water and diethyl ether to give the title compound 3.70 g as off-white solid. Yield 83.5%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08129386B2 |
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| Source dataset | uspto-grants-2012_03 |
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| ORD ID | ord-e6ffe23366c84afa9b6602826bbe8b94 |
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| Source note | uspto-grants-2012_03 |
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