HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1091577Generated: November 2, 2026
Hydrochloric Acid → HCID 178524759, compound
https://huagongshe.com/reaction/1091577
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 4-acetoxy-6-(acetoxymethyl)-5-(benzyloxy)nicotinate | HCID 59600561 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178524759 | HCID 178524759 | 68% |
Reaction Steps
To a solution of the compound 8 (46.8 g, 125 mmol) in methanol (140 ml) was added a 2N aqueous sodium hydroxide solution (376 ml) under ice-cooling, and this was stirred at 50° C. for 40 minutes. To the reaction solution were added diethyl ether and 2N hydrochloric acid under ice-cooling, and precipitated crystals were filtered. Resulting crystals were washed with water and diethyl ether to obtain 5-benzyloxy-4-hydroxy-6-hydroxymethyl-nicotinic acid 9 (23.3 g, 68%) as a colorless crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08129385B2 |
|---|
| Source dataset | uspto-grants-2012_03 |
|---|
| ORD ID | ord-58931085b7b144af8545df6cb110b6c6 |
|---|
| Source note | uspto-grants-2012_03 |
|---|
