反应详情

温度

50 °C

2-(6-Nitrobenzothiazol-2(3H)-ylidene)-2-(4-trifluoromethylpyrimidin-2-yl)acetonitrile (296 mg, 0.81 mmol) was dissolved in concentrated sulfuric acid (3.0 mL). The reddish mixture was stirred at 50° C. for 8 hr, then poured into cold water (25 mL). The yellow precipitate was collected by filtration, washed with hexanes (30 mL), and dried under vacuum to give 2-[6-nitrobenzothiazol-2(3H)-ylidene]-2-(4-trifluoromethylpyrimidin-2-yl)acetamide (280 mg, 89% yield) as an orange solid.

1. filtrationThe yellow precipitate was collected by filtration
2. washwashed with hexanes (30 mL)
3. customdried under vacuum