反应详情

1-((6-Methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)methyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde (100 mg, 0.292 mmol) was dissolved in a 1:1 DCM:MeOH solution (2 mL) and sodium borohydride (33 mg, 0.876 mmol) added. After 30 min the mixture was quenched by addition of water (1 mL) then concentrated in vacuo. Purification by flash column chromatography-silica gel and elution with 3% MeOH:DCM resulted in a white solid which was recrystallised from isopropanol and freeze dried to give the title compound as a white solid (28 mg, 0.081 mmol, 28%).

1. customAfter 30 min the mixture was quenched by addition of water (1 mL)
2. concentrationthen concentrated in vacuo
3. customPurification
4. washby flash column chromatography-silica gel and elution with 3% MeOH
5. customDCM resulted in a white solid which
6. customwas recrystallised from isopropanol and freeze
7. customdried