HCID 57791810, compound → HCID 57791826, compound

Participants

Reaction Steps

4-(1,3-difluoropropan-2-yloxy)pyridine (27) (0.098 mg, 0.57 μmol) and 5% rhodium on alumina (0.02 g, 2.56 μmol) in MeOH (50 mL) were stirred under an atmosphere of hydrogen at 5 bar and 25° C. for 16 hours. The catalyst was filtered and washed with MeOH and the solvent evaporated to afford the desired compound as a gum (0.082 g, 81%); 1H NMR (400.132 MHz, CDCl3) δ 1.43-1.48 (1H, m), 1.60-1.71 (1H, m), 1.82-2.15 (3H, m), 2.42 (1H, s), 2.84-2.92 (1H, m), 3.09-3.14 (1H, m), 3.25-3.30 (1H, m), 3.82-3.95 (1H, m), 4.35-4.44 (2H, m), 4.47-4.56 (2H, m).

Provenance & Evidence