Thionyl Chloride → (3-Bromophenyl)acetyl chloride

HRID 1091731Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1091731
S(Cl)([Cl:3])=O.[Br:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([OH:15])=O)[CH:9]=[CH:10][CH:11]=1>C(Cl)Cl>[Br:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([Cl:3])=[O:15])[CH:9]=[CH:10][CH:11]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 74653(3-Bromophenyl)acetic acid

Produkt 1

HCID 13486899(3-Bromophenyl)acetyl chlorideAusbeute 96,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Thionyl chloride (2.035 mL, 27.90 mmol) was added to 2-(3-bromophenyl)acetic acid (1.500 g, 6.98 mmol) in DCM (30 mL). The resulting solution was stirred at room temperature for 18 hours. The resulting mixture was evaporated to dryness and the residue was azeotroped with toluene to afford crude product (1.570 g, 96% yield), which was used without further purification.

Aufarbeitung

  1. customThe resulting mixture was evaporated to dryness
  2. customthe residue was azeotroped with toluene

Quellen und Nachweise

ORD-Eintrag
ord-ded89fa3373a4da09d219f0541954b00
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08129380B2

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