Potassium Hydroxide → HCID 66592817, compound

HRID 1091852Notes

Reaction equation

HRID 1091852 reaction equation
C(OC([N:6]1[CH2:11][CH2:10][C:9]2[O:12][C:13]3[C:18]([O:19][CH3:20])=[CH:17][CH:16]=[C:15]([C:21]([OH:23])=[O:22])[C:14]=3[C:8]=2[CH2:7]1)=O)C.[OH-].[K+]>CO.O>[CH3:20][O:19][C:18]1[C:13]2[O:12][C:9]3[CH2:10][CH2:11][NH:6][CH2:7][C:8]=3[C:14]=2[C:15]([C:21]([OH:23])=[O:22])=[CH:16][CH:17]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 66592347HCID 66592347, compound

Product 1

HCID 66592817HCID 66592817, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

2-ethoxycarbonyl-6-methoxy-1,2,3,4-tetrahydro[1]benzofuro[3,2-c]pyridine-9-carboxylic acid (from step 9 of example 9) (1.8 g, 6.10 mmol) was dissolved in methanol (10 ml). To this KOH (6.8 g, 122.03 mmol) dissolved in 10 ml water was added and reaction mixture was refluxed overnight. Reaction mixture was concentrated and residue was diluted with water (25 ml) and neutralized with (15 ml) saturated ammonium chloride solution. The precipitate obtained was filtered and dried under vacuum. Yield=1.6 g (pale yellow solid).

Workup

  1. additionwas added
  2. customreaction mixture
  3. temperaturewas refluxed overnight
  4. customReaction mixture
  5. concentrationwas concentrated
  6. additionresidue was diluted with water (25 ml) and neutralized with (15 ml) saturated ammonium chloride solution
  7. customThe precipitate obtained
  8. filtrationwas filtered
  9. customdried under vacuum

Sources & evidence

ORD record
ord-33b64e30b3cf464798ec8ff1244841e9
Source dataset
uspto-grants-2012_03
Patent number
US08129401B2

Reaction notes

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