Dimethyl Sulfate → Methyl-7-cyclopentyloxy-2-methylbenzo[b]furan-4-carboxylate

Participants

Reaction Conditions

Reaction Steps

To a suspension of 7-cyclopentyloxy-2-methylbenzo[b]furan-4-carboxylic acid (40.0 g, 0.153 moles) and potassium carbonate (42.0 g, 0.184) in acetone (400 mL) added dimethyl sulfate (24.0 g, 0.307 moles) and refluxed for 4-5 hrs. acetone (305 mL) was distilled off and reaction mixture was cooled to 5° C., ice cold water (500 mL) was and the solid separated was filtered, washed with water (2×100 mL0 and dried to get off white solid (43.0 g).

Provenance & Evidence