Acetic Anhydride → HCID 57531383, compound

Participants

Reaction Steps

To a vial containing 4-(aminomethyl)-1-[2-(2,6-diethylphenyl)-6-methyl-5-({methyl[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]amino}methyl)pyrimidin-4-yl]piperidin-4-ol (25 mg, 0.047 mmol) in DMA (1.0 mL) is added K2CO3 (33 mg, 5.0 eq., 0.24 mmol) and acetic anhydride (0.023 mL, 5.0 eq., 0.24 mmol) and allowed to stir at room temperature for 16 h. EtOAc (2.0 mL) and sat NaHCO3 (2.0 mL) are then added and the organic layer is transferred directly onto a SiO2 plate and the product is eluted with 20:1 CHCl3:MeOH affording the title compound as a white foam. [mass expected (569.78); mass found (569.30)].

Provenance & Evidence