HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (trans)-2-[[(4-Biphenyl)sulfonyl]amino]cyclohexanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (1,1'-Biphenyl)-4-sulphonyl chloride | HCID 74192 | — |
| Reactant | trans-2-Aminocyclohexanecarboxylic acid | HCID 2724640 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (trans)-2-[[(4-Biphenyl)sulfonyl]amino]cyclohexanecarboxylic acid | HCID 66588543 | — |
Reaction Steps
This compound was prepared from trans-2-amino-1-cyclohexanecarboxylic acid (1.0 g, 7.0 mmol) by reacting it with sodium carbonate (1.48 g, 14.0 mmol) and biphenyl-4-sulfonyl chloride (2.02 g, 8.0 mmol) in dioxane:water (70:35 mL) in the same manner as described in Example 1. The yield was 1.48 g (59%), the melting point was 220-222° C., and mass spectrometry revealed a molecular ion peak (MH)+ at m/z 360.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08129406B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-cc4de97506db4be5bf7ffcc4f31a10e9 |
| Source note | uspto-grants-2012_03 |