HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (trans)-2-[(4-Phenoxybenzenesulfonyl)amino]cyclohexanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | trans-2-Aminocyclohexanecarboxylic acid | HCID 2724640 | — |
| Reactant | 4-Phenoxybenzene-1-sulfonyl chloride | HCID 2794756 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (trans)-2-[(4-Phenoxybenzenesulfonyl)amino]cyclohexanecarboxylic acid | HCID 66588486 | — |
Reaction Steps
This compound was prepared from trans-2-amino-1-cyclohexanecarboxylic acid (1.0 g, 7.0 mmol) by reacting it with sodium carbonate (1.48 g, 14.0 mmol) and 4-phenoxybenzenesulfonyl chloride (2.25 g, 8.38 mmol) in dioxane:water (40:20 mL) in the same manner as described in Example 1. This yielded 1.275 g (48%). The melting point was 192-194° C. Mass spectrometry revealed a molecular ion (MH)+ peak at m/z 376.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08129406B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-f6f59a4854ea43aeb5a3cd6e2b5a29b9 |
| Source note | uspto-grants-2012_03 |