1-Octen-3-one → 1-[4-(3-Phenylpropyl)piperidin-1-yl]octan-3-one

HRID 1091975Notes

Reaction equation

HRID 1091975 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16]=[CH:17][C:18](=[O:24])[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]>C(O)C>[C:1]1([CH2:7][CH2:8][CH2:9][CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][C:18](=[O:24])[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:14][CH2:15]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 613461-Octen-3-oneHCID 876784-(3-Phenylpropyl)piperidine

Product 1

HCID 115372371-[4-(3-Phenylpropyl)piperidin-1-yl]octan-3-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 equivalent of 4-(3-phenylpropyl)piperidine was reacted with 1 equivalent of 1-octen-3-one in ethanol, at room temperature. The product was worked up and purified on a column of silica. The results of the NMR and mass spectrometry analyses were in accordance with the expected structure.

Workup

  1. custompurified on a column of silica
  2. customThe results of the NMR and mass spectrometry analyses

Sources & evidence

ORD record
ord-9ecd9f9081954e8ab6821f36cc572836
Source dataset
uspto-grants-2012_03
Patent number
US08129409B2

Reaction notes

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