Hydrochloric Acid → HCID 44469961, compound

Participants

Reaction Steps

4M HCl in dioxane (30 mL) was added to tert-butyl 4-[4-(1,1,2,2-tetrafluoroethoxy)phenoxy]piperidine-1-carboxylate (3.3 g). The mixture was stirred at ambient temperature for 30 minutes. The mixture was then concentrated at reduced pressure and triturated with diethyl ether. The resulting precipitate was filtered, washed with diethyl ether and dried under vacuum to give 4-[4-(1,1,2,2-tetrafluoroethoxy)phenoxy]piperidine as the hydrochloride salt (2.76 g); NMR Spectrum: (DMSOd6) 1.75-1.91 (m, 2H), 2.02-2.17 (m, 2H), 2.95-3.12 (m, 2H), 3.13-3.29 (m, 2H), 4.57-4.69 (m, 1H), 6.75 (tt, 1H), 7.06 (d, 2H), 7.19 (d, 2H), 8.95 (bs, 2H); Mass Spectrum: M+H+ 294.

Provenance & Evidence