Diisopropylethylamine → HCID 178458609, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2,6-dichloro-3-nitropyridine (1.0 g, 5.3 mmol) and DIEA (0.77 ml, 4.4 mmol) in THF (20 ml) was added 5-isopropoxy-1H-pyrazol-3-amine (0.50 g, 3.5 mmol). The reaction mixture was stirred at 25° C. for 3 days and 60° C. for 1 hour. The solvent was removed under reduced pressure and the resulted residue was purified by column chromatography (hexane-EtOAc=3:1) to give the title compound as a yellow solid (0.62 g, 59%). 1H NMR (400 MHz) 12.25 and 11.66 (s, 1H), 10.46 and 10.13 (s, 1H), 8.56 (m, 1H), 7.11 and 7.02 (d, J=8.4 Hz, 1H), 6.08 and 5.97 (s, 1H), 4.70 and 4.48 (m, 1H), 1.32 and 1.27 (d, J=6.0 Hz, 6H). MS: Calcd.: 297; Found: [M+H]+ 298.

Provenance & Evidence