N-Benzylglycine ethyl ester → HCID 66593062, compound

Participants

Reaction Steps

2-Adamantyl-isocyanate (CAS 71189-14-5, made from 2-aminoadamantane according to Eur. J. Med. Chem. 28 (1), 1993, 37-45, 500 mg) and commercially available benzylamino-acetic acid ethyl ester (572 mg) were dissolved in absolute ether (25 mL) under argon and stirred at RT for 12 hours. A colorless precipitate was formed. The reaction mixture was concentrated in vacuo and the residue was triturated with hexanes (30 mL) for one hour. The suspension was filtered and the solid was dried in vacuo to give (3-adamantan-2-yl-1-benzyl-ureido)-acetic acid ethyl ester (823 mg). MS (ESI): 371.2 (MH+).

Provenance & Evidence