(Bromomethyl)cyclobutane → HCID 57495525, compound

HRID 1092309Notes

Reaction equation

HRID 1092309 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[N:11]1[CH:15]=[C:14]([CH:16]([CH3:18])[CH3:17])[NH:13][C:12]1=[O:19])[CH2:8]2.Br[CH2:21][CH:22]1[CH2:25][CH2:24][CH2:23]1>>[CH:1]12[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[CH:2]1[N:11]1[CH:15]=[C:14]([CH:16]([CH3:17])[CH3:18])[N:13]([CH2:21][CH:22]3[CH2:25][CH2:24][CH2:23]3)[C:12]1=[O:19])[CH2:10]2

Participants

3

Reactant 2

HCID 2734658(Bromomethyl)cyclobutaneHCID 24964431HCID 24964431, compound

Product 1

HCID 57495525HCID 57495525, compound

Procedure

This material was obtained in analogy to the procedure outlined in example 23 from 1-adamantan-2-yl-4-isopropyl-1,3-dihydro-imidazol-2-one (obtained in example 8, 100 mg) by alkylation with bromomethylcyclobutane (86 mg). 1-Adamantan-2-yl-3-cyclobutylmethyl-4-isopropyl-1,3-dihydro-imidazol-2-one was obtained as a light yellow oil (51 mg). MS (EI): 328.3 (M+).

Workup

  1. customThis material was obtained in analogy to the procedure

Sources & evidence

ORD record
ord-9199a0d3ffdb4c0097c98672f27bbeaa
Source dataset
uspto-grants-2012_03
Patent number
US08129423B2

Reaction notes

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