2-Isocyanatoadamantane → HCID 57495623, compound

HRID 1092315Notes

Reaction equation

HRID 1092315 reaction equation
Cl.[NH2:2][CH:3]([C:11](=[O:15])[CH:12]([CH3:14])[CH3:13])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH:16]12[CH2:25][CH:20]3[CH2:21][CH:22]([CH2:24][CH:18]([CH2:19]3)[CH:17]1[N:26]=[C:27]=[O:28])[CH2:23]2>>[CH:18]12[CH2:24][CH:22]3[CH2:21][CH:20]([CH2:25][CH:16]([CH2:23]3)[CH:17]1[NH:26][C:27]([NH:2][CH:3]([CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)[C:11](=[O:15])[CH:12]([CH3:13])[CH3:14])=[O:28])[CH2:19]2

Participants

3

Reactant 2

HCID 128826302-IsocyanatoadamantaneHCID 574956242-Amino-4-methyl-1-phenyl-pentan-3-one hydrochloride

Product 1

HCID 57495623HCID 57495623, compound

Procedure

This material was obtained in analogy to example 7, step A] from known 2-amino-4-methyl-1-phenyl-pentan-3-one hydrochloride (CAS 472995-82-7, see J. Heterocyclic Chem. 39 (2), 2002, 375-382, 249 mg) and 2-adamantyl isocyanate (194 mg). 1-Adamantan-2-yl-3-(1-benzyl-3-methyl-2-oxo-butyl)-urea was obtained as a white solid (245 mg). MS (ISP): 369.5 (MH+).

Workup

  1. customThis material was obtained in analogy to example 7, step A]

Sources & evidence

ORD record
ord-a60ae3615d4b41cea2d810ca220d4f2c
Source dataset
uspto-grants-2012_03
Patent number
US08129423B2

Reaction notes

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