1,1,1-Trifluoro-2-iodoethane → HCID 24965850, compound

Participants

Reaction Steps

This material was obtained in analogy to the procedure outlined in example 23 from 4-isobutyl-1-(2-trifluoromethyl-phenyl)-1,3-dihydro-imidazol-2-one (obtained in example 18, 200 mg) by alkylation with 2,2,2-trifluoroethyl iodide (162 mg). In contrast to the other, similar reactions, alkylation occurred predominantly at C-5 instead of N-3 of the imidazolone core. Thus, this reaction yielded 4-isobutyl-5-(2,2,2-trifluoro-ethyl)-1-(2-trifluoromethyl-phenyl)-1,3-dihydro-imidazol-2-one as a light yellow solid (36 mg). MS (ESI): 367.0 (MH+).

Provenance & Evidence