Methyl iodide → HCID 24965851, compound

HRID 1092323Notes

Reaction equation

HRID 1092323 reaction equation
[CH2:1]([C:5]1[NH:6][C:7](=[O:20])[N:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:16]([F:19])([F:18])[F:17])[CH:9]=1)[CH:2]([CH3:4])[CH3:3].I[CH3:22]>>[CH2:1]([C:5]1[N:6]([CH3:22])[C:7](=[O:20])[N:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:16]([F:19])([F:17])[F:18])[CH:9]=1)[CH:2]([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 24964795HCID 24964795, compound

Product 1

HCID 24965851HCID 24965851, compound

Procedure

This material was obtained in analogy to the procedure outlined in example 23 from 4-isobutyl-1-(2-trifluoromethyl-phenyl)-1,3-dihydro-imidazol-2-one (obtained in example 18, 200 mg) by alkylation with iodomethane (110 mg). 4-Isobutyl-3-methyl-1-(2-trifluoromethyl-phenyl)-1,3-dihydro-imidazol-2-one was obtained as a colorless oil (140 mg). MS (ESI): 299.2 (MH+).

Workup

  1. customThis material was obtained in analogy to the procedure

Sources & evidence

ORD record
ord-776ee9bdea6140b1bdaf3728ffc139f3
Source dataset
uspto-grants-2012_03
Patent number
US08129423B2

Reaction notes

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