HCID 57495524, compound → HCID 24966208, compound

Participants

Reaction Steps

These materials were obtained in analogy to the procedure outlined in example 50 from 1-adamantan-2-yl-3-cyclopropylmethyl-4-isopropyl-1,3-dihydro-imidazol-2-one (53 mg, obtained in example 23) by hydrogenation over platinum on charcoal. Separation of the crude reaction mixture by flash chromatography (silica gel, ethyl acetate/heptane 9:1) provided 1-adamantan-2-yl-3-isobutyl-4-isopropyl-imidazolidin-2-one as the less polar component (16 mg, Rf=0.7, ethyl acetate/heptane 1:1, MS (ESI): 319.3 (MH+)) and 1-adamantan-2-yl-3-cyclopropylmethyl-4-isopropyl-imidazolidin-2-one as the more polar component (24 mg, Rf=0.65, ethyl acetate/heptane 1:1, MS (ESI): 317.3 (MH+).

Provenance & Evidence