752922-40-0 → HCID 55285240, compound

HRID 1092342Notes

Reaction equation

HRID 1092342 reaction equation
[NH2:1][C:2]([CH:8]1[CH2:10][CH2:9]1)([CH:5]1[CH2:7][CH2:6]1)[C:3]#[N:4].[H-].C([Al+]CC(C)C)C(C)C>>[CH:5]1([C:2]([CH:8]2[CH2:10][CH2:9]2)([NH2:1])[CH2:3][NH2:4])[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 16770335752922-40-0HCID 21225700Diisobutylaluminumhydride

Product 1

HCID 55285240HCID 55285240, compound

Procedure

This material was obtained according to example 65, step A] α-amino-α-cyclopropyl-cyclopropaneacetonitrile (266 mg) by reduction with diisobutylaluminiumhydride (20% in toluene, 8.1 mL) as a colorless semisolid (106 mg) after purification by flash chromatography (ethyl acetate/MeOH/NH4OH 1:1:0.1). 1H-NMR (CDCl3): 2.66 (s, 2H); 1.70 (s, br, >4H, 4 NH and H2O), 0.71 (m, 2H), 0.40-0.21 (m, 8H).

Workup

  1. customThis material was obtained
  2. customafter purification by flash chromatography (ethyl acetate/MeOH/NH4OH 1:1:0.1)

Sources & evidence

ORD record
ord-8c05cb8030fd4363b5c41eff3354c1e0
Source dataset
uspto-grants-2012_03
Patent number
US08129423B2

Reaction notes

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