Acetic Acid → 1-(Cyclopropylamino)cycloheptanecarbonitrile

Participants

Reaction Steps

5 g (44.57 mmol) of Cycloheptanone and 4.1 g of potassium cyanide were added to a solution of 4.38 ml (62.4 mmol) cyclopropylamine and 3.56 ml (62.4 mmol) of acetic acid in 50 ml MeOH. The reaction-mixture was stirred for 24 h, and then it was concentrated under reduced pressure, taken up in EtOAc and washed with water. The organic layer was concentrated under reduced pressure to give 6.84 g almost pure 1-Cyclopropylamino-cycloheptanecarbonitrile. MS (ESI): 179.3 (M+H)

Provenance & Evidence