Boron Trichloride → HCID 86619957, compound

Participants

Reaction Steps

150 mg (0.5 mmol) of 1-Cyclopropyl-3-(4-methoxy-phenyl)-1,3-diaza-spiro[4.5]decan-2-one, product of example 158, was treated with 1.5 ml (1.5 mmol) of boron trichloride (1.0M solution in Heptane). The reaction mixture was stirred at RT for 20 h. The reaction mixture was then taken up in Ethyl acetate and washed with 1N HCl and water. The raw product was purified by chromatography with DCM/Ethyl acetate 9:1 to 4:1 giving 30 mg of a light brown solid. MS (ESI): 287.0 (MH+).)

Provenance & Evidence