Methylamine → HCID 13809007, compound

Participants

Reaction Steps

A solution of known benzyloxy-acetaldehyde (10 g) in 25 mL ether, was added to an aqueous solution of methylamine (5.16 g of a 40% solution in water) at 0° C. followed by addition of NaCN (6.4 g dissolved in 10 mL water). The reaction mixture was stirred overnight at room temperature. The reaction was monitored by TLC and after completion, the ether layer was separated. The aqueous layer was extracted with 2×30 mL ethyl acetate and the combined organic layers were then dried over sodium sulfate, filtered and the volatiles where then concentrated to afford the crude product which was purified by column chromatography using basic alumina to give 3-benzyloxy-2-methylamino-propionitrile (5.0 g) as a dark brown oil.

Provenance & Evidence