HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → HCID 59596854, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Trimethylaluminum | HCID 16682925 | — |
| Reactant | HCID 59596844 | HCID 59596844 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Heptane | HCID 8900 | — |
| Product | HCID 59596854 | HCID 59596854 | 52% |
Reaction Steps
This compound was synthesized according to the procedure described in Scheme 6, step B, using 115 mg of 2-[2-[4-(3-fluoro-benzyloxy)-3-methoxy-phenyl]-ethylamino]-2-phenyl-acetic acid methyl ester (0.27 mmol), 1.06 ml (2.1 mmol) of a 2 M solution of dimethylamine in tetrahydrofuran and 0.53 ml (1.06 mmol) of a 2 M solution of trimethyl aluminium in heptane. 66 mg (52% yield) of the title compound were isolated as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08129427B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-f41ec9b08c4644c5b76b05cf51bd0e39 |
| Source note | uspto-grants-2012_03 |