huagongshe.com
HRID1092494

反应详情

EQUATION

反应方程式

HRID 1092494 的结构方程式

REACTANTS

反应物

3
结构：O=Cc1cccc(C(F)(F)F)c1
HCID67990

alpha,alpha,alpha-Trifluoro-m-tolualdehyde

C8H5F3O

结构：O=C(N[C@H]1CC[C@H]2CNC[C@H]21)C(C1CCCCC1)C1CCCCC1
HCID46213053

未命名化合物

结构：O=C(N[C@@H]1CC[C@H]2CNC[C@H]21)C(C1CCCCC1)C1CCCCC1
HCID54674170

未命名化合物

PRODUCTS

生成物

1
结构：O=C(N[C@@H]1CC[C@H]2CN(CCC(c3ccccc3)c3ccccc3)C[C@H]21)C(C1CCCCC1)C1CCCCC1
HCID66590126

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by substituting 3,3-diphenylpropanal for 3-(trifluoromethyl)benzaldehyde and 2,2-dicyclohexyl-N-[(3aS,4R,6aR)-octahydrocyclopenta[c]pyrrol-4-yl]acetamide from Example 74 for 2,2-dicyclohexyl-N-[(3aS,4S,6aR)-octahydrocyclopenta[c]pyrrol-4-yl]acetamide in the procedure described for Example 54: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.10 (d, J=7.7, 1H), 7.45 (d, J=7.3, 2H), 7.42 (d, J=7.1, 3H), 7.38-7.30 (m, 5H), 4.56-4.48 (m, 1H), 4.27 (t, J=7.5, 1H), 2.92-2.86 (m, 1H), 2.59-2.48 (m, J=6.7, 14.0, 2H), 2.38-2.26 (m, 5H), 2.21-2.12 (m, 2H), 2.05 (t, J=7.4, 1H), 1.97 (dd, J=8.3, 17.0, 2H), 1.94-1.85 (m, 4H), 1.81 (d, J=11.8, 2H), 1.72 (d, J=13.2, 4H), 1.66 (dd, J=7.4, 11.8, 1H), 1.61 (d, J=12.6, 2H), 1.48 (ddd, J=3.4, 12.8, 15.5, 3H), 1.30-1.19 (m, 4H), 1.19-1.06 (m, 4H); MS (ESI+) m/z 527 (M+H)+.