1-Phenylcyclopentanecarboxylic acid → HCID 66595166, compound

HRID 1092557Notes

Reaction equation

HRID 1092557 reaction equation
C1(C2(C(O)=[O:13])CCCC2)C=CC=CC=1.[C:15]1([C@@H:21]([N:23]2[CH2:27][C@@H:26]3[CH:28](N)[CH2:29][CH2:30][C@@H:25]3[CH2:24]2)[CH3:22])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(N1C[C@H]2C(N)CC[C@H]2C1)C1C=CC=CC=1>>[C:15]1([C@@H:21]([N:23]2[CH2:27][C@H:26]3[C:28](=[O:13])[CH2:29][CH2:30][C@H:25]3[CH2:24]2)[CH3:22])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 661671-Phenylcyclopentanecarboxylic acidHCID 66590436HCID 66590436, compoundHCID 68411161(3aS*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-amine

Product 1

HCID 66595166HCID 66595166, compound

Procedure

The title compounds were prepared by substituting (S)-2-phenylbutanoic acid for 1-phenylcyclopentanecarboxylic acid and (3aR,6aS)-2-((S)-1-phenylethyl)octahydrocyclopenta[c]pyrrol-4-amine for (3aS*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Examples 1 and 2.

Sources & evidence

ORD record
ord-35678cbddeb2418ab139de8cf2db4fcc
Source dataset
uspto-grants-2012_03
Patent number
US08129417B2

Reaction notes

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