3-(2,5-Dichloropyrimidin-4-yl)-1H-indole → 5-chloro-N-[5-fluoro-2-methoxy-4-[4-(4-methylpiperazin-1-yl)-1-piperidyl]phenyl]-4-(1H-indol-3-yl)pyrimidin-2-amine

HRID 109259Notes

Reaction equation

HRID 109259 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:17])[c:6](-[c:8]2[cH:9][nH:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]23)[n:7]1.[F:18][c:19]1[c:20]([N:28]2[CH2:29][CH2:30][CH:31]([N:34]3[CH2:35][CH2:36][N:37]([CH3:40])[CH2:38][CH2:39]3)[CH2:32][CH2:33]2)[cH:21][c:22]([O:26][CH3:27])[c:23]([NH2:24])[cH:25]1>>[c:2]1([NH:24][c:23]2[c:22]([O:26][CH3:27])[cH:21][c:20]([N:28]3[CH2:29][CH2:30][CH:31]([N:34]4[CH2:35][CH2:36][N:37]([CH3:40])[CH2:38][CH2:39]4)[CH2:32][CH2:33]3)[c:19]([F:18])[cH:25]2)[n:3][cH:4][c:5]([Cl:17])[c:6](-[c:8]2[cH:9][nH:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]23)[n:7]1

Participants

3

Reactant 2

HCID 566553763-(2,5-Dichloropyrimidin-4-yl)-1H-indoleHCID 580714395-Fluoro-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline

Product 1

HCID 580714845-chloro-N-[5-fluoro-2-methoxy-4-[4-(4-methylpiperazin-1-yl)-1-piperidyl]phenyl]-4-(1H-indol-3-yl)pyrimidin-2-amine

Sources & evidence

ORD record
ord-9584adfe41954b2f8934b396896f6bd6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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