huagongshe.com
HRID1092597

反应详情

EQUATION

反应方程式

HRID 1092597 的结构方程式

REACTANTS

反应物

3
反应SMILES：CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O
HCID83170

L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-

C11H21NO4

反应SMILES：N[C@@H]1CC[C@H]2CN(S(=O)(=O)c3cccc(C(F)(F)F)c3)C[C@H]21
HCID66590613

未命名化合物

反应SMILES：N[C@H]1CC[C@@H]2CN(Cc3ccccc3)C[C@@H]21
HCID66591011

未命名化合物

PRODUCTS

产物

1
反应SMILES：CCC[C@H](NCC(C)(C)C)C(=O)N[C@@H]1CC[C@H]2CN(S(=O)(=O)c3cccc(C(F)(F)F)c3)C[C@H]21
HCID68413250

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by substituting (S)-2-(neopentylamino)pentanoic acid from Step A of Example 246 for N-(tert-butoxycarbonyl)-L-leucine and (3aS,4R,6aR)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-amine from Step A of Example 254 for (3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 221: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.37-8.38 (bs, 1H), 8.18 (d, J=7.9 Hz, 1H), 8.09-8.11 (m, 1H), 7.90-7.92 (m, 1H), 7.71 (t, J=7.8 Hz, 1H), 4.20-4.27 (m, 1H), 3.88 (dd, J=9.9, 2.8 Hz, 1H), 3.20 (dd, J=6.6, 3.1 Hz, 1H), 3.16-3.20 (m, 1H), 3.14 (dd, J=9.9, 7.8 Hz, 1H), 2.96 (dd, J=9.6, 7.3 Hz, 1H), 2.46-2.61 (m, 2H), 2.38 (d, J=11.3 Hz, 1H), 2.33 (d, J=11.3 Hz, 1H), 1.92-1.99 (m, 1H), 1.83-1.90 (m, 1H), 1.76-1.83 (m, 1H), 1.66-1.87 (m, 1H), 1.61-1.70 (m, 1H), 1.38-1.58 (m, 3H), 1.26-1.37 (m, 1H), 0.92 (s, 9H), 0.85 (t, J=7.3 Hz, 3H); MS (ESI+) m/z 504 (M+H)+.