L-Leucine, N-((1,1-dimethylethoxy)carbonyl)- → HCID 91247040, compound

Participants

Reaction Steps

The title compound was prepared by substituting N-(tert-butoxycarbonyl)-L-neopentylglycine for N-(tert-butoxycarbonyl)-L-leucine and (3aR,4S,6aS)-2-(2-(methylsulfonyl)pyrimidin-5-yl)octahydrocyclopenta[c]pyrrol-4-amine from Step A for (3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 221: 1H NMR (400 MHz, pyridine-d5) δ ppm 8.34 (s, 2H), 7.79 (ddd, J=3.5, 1.7, 0.7, 1H), 7.10-6.93 (m, 1H), 4.52 (td, J=8.2, 4.7, 1H), 4.27 (qd, J=7.1, 5.4, 1H), 3.90 (d, J=11.1, 3H), 3.85 (dd, J=8.1, 3.9, 1H), 3.77 (dd, J=12.1, 7.6, 1H), 3.67 (dd, J=11.8, 7.9, 1H), 3.42 (dd, J=11.8, 4.1, 1H), 2.79-2.63 (m, 2H), 2.16-2.02 (m, 2H), 1.97-1.83 (m, 1H), 1.72 (dd, J=14.3, 8.0, 1H), 1.68-1.56 (m, 1H), 1.49 (s, 9H), 1.44-1.30 (m, 1H), 0.99 (s, 9H); MS (ESI+) m/z 510 (M+H)+.

Provenance & Evidence