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3-Methylpiperidine → 5-Fluoro-4-(3-methylpiperidino)-6-(2-pentynyloxy)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methylpiperidine | HCID 79081 | — |
| 反応物 | 4-Chloro-5-fluoro-6-(2-pentynyloxy)pyrimidine | HCID 59341120 | — |
| 生成物 | 5-Fluoro-4-(3-methylpiperidino)-6-(2-pentynyloxy)pyrimidine | HCID 11507380 | 89% |
反応手順
0.2 g of 4-chloro-5-fluoro-6-(2-pentynyloxy)pyrimidine and 0.29 g of 3-methylpiperidine were mixed and left for 3 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.23 g of 5-fluoro-4-(3-methylpiperidino)-6-(2-pentynyloxy)pyrimidine (hereinafter, referred to as Compound (10)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08129526B2 |
| 出典データセット | uspto-grants-2012_03 |
| ORD ID | ord-c34d35c64b0247e4a98ed2082ce25a3a |
| 出典メモ | uspto-grants-2012_03 |