HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)piperidine → 4-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)piperidine | HCID 2760776 | — |
| Reactant | 4-(2-Butynyloxy)-6-chloropyrimidine | HCID 12137602 | — |
| Product | 4-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine | HCID 57672951 | 61.4% |
Reaction Steps
0.3 g of 4-chloro-6-(2-butynyloxy)pyrimidine and 0.25 g of 3-trifluoromethylpiperidine were mixed and left for 10 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.30 g of 4-(2-butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine (hereinafter, referred to as Compound (24)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08129526B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-ef0b674b518248ccaf606af079f92f12 |
| Source note | uspto-grants-2012_03 |