HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,6-Tetrahydropyridine → 1-(6-(2-Butynyloxy)-5-fluoropyrimidin-4-yl)-1,2,3,6-tetrahydropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,6-Tetrahydropyridine | HCID 12750 | — |
| Reactant | 4-(2-Butynyloxy)-5-fluoro-6-chloropyrimidine | HCID 22599717 | — |
| Product | 1-(6-(2-Butynyloxy)-5-fluoropyrimidin-4-yl)-1,2,3,6-tetrahydropyridine | HCID 59341148 | 101.4% |
Reaction Steps
0.2 g of 4-(2-butynyloxy)-6-chloro-5-fluoropyrimidine and 0.25 g of 1,2,3,6-tetrahydropyridine were mixed and left for 3 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.25 g of 1-(6-(2-butynyloxy)-5-fluoropyrimidin-4-yl)-1,2,3,6-tetrahydropyridine (hereinafter, referred to as Compound (53)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08129526B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-fa3329f7cb144f92a6538ebcedd82631 |
| Source note | uspto-grants-2012_03 |