HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1092800Generated: November 2, 2026
Methyl Acrylate → (S)-Methyl 3-(4-(cyclopropyl(2,3-dichlorobenzyl)amino)-1-hydroxy-4-oxobutan-2-ylamino)propanoate
https://huagongshe.com/reaction/1092800
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl Acrylate | HCID 7294 | — |
| Reactant | (S)-3-Amino-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-hydroxybutanamide | HCID 66590104 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-Methyl 3-(4-(cyclopropyl(2,3-dichlorobenzyl)amino)-1-hydroxy-4-oxobutan-2-ylamino)propanoate | HCID 66593719 | — |
Reaction Steps
Into a 250 mL round bottom was 4B (10.6 g, 33.4 mmol) and methanol (90 mL). Methyl acrylate (3.16 g, 36.8 mmol, 1.1 eq) was added and the reaction was heated to 50° C. overnight. Solvent was removed under vacuum. The residue was used in the next step without further purification. ESI-MS:m/z 403.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08129538B1 |
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| Source dataset | uspto-grants-2012_03 |
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| ORD ID | ord-286efc364fd4444291b05e0644369ab7 |
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| Source note | uspto-grants-2012_03 |
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